The Metabolic Classroom with Dr. Ben Bikman Insulin Resistance and Cognition
Apr 30, 2021
Explore the impact of insulin resistance on brain energy and cognition, with a focus on Alzheimer's disease research. Discover the link between insulin resistance, glucose metabolism, and cognition in Alzheimer's. Learn about reversing insulin resistance with ceramides and a low-carb diet. Understand the role of APO-E4 genotype and insulin resistance in Alzheimer's risk. Delve into the diverse audience of the podcast and making complex topics accessible for all listeners.
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Brain Energy and Insulin Resistance
- The brain, especially the hippocampus, needs insulin for glucose uptake and energy.
- Insulin resistance in the brain can create an "energy gap", impacting learning and memory.
Ketones as Alternative Fuel
- People with mild cognitive impairment or Alzheimer's show reduced brain glucose usage.
- However, their ketone usage remains normal, suggesting an alternative energy pathway.
Genetic Evidence for Ketone Use
- Alzheimer's brains show reduced expression of genes related to glucose metabolism.
- Ketone metabolism-related genes remain largely unaffected, further supporting ketones as alternative fuel.