The Metabolic Classroom with Dr. Ben Bikman cover image

The Metabolic Classroom with Dr. Ben Bikman

Insulin Resistance and Cognition

Apr 30, 2021
Explore the impact of insulin resistance on brain energy and cognition, with a focus on Alzheimer's disease research. Discover the link between insulin resistance, glucose metabolism, and cognition in Alzheimer's. Learn about reversing insulin resistance with ceramides and a low-carb diet. Understand the role of APO-E4 genotype and insulin resistance in Alzheimer's risk. Delve into the diverse audience of the podcast and making complex topics accessible for all listeners.
52:08

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Quick takeaways

  • Insulin resistance in the brain leads to an energy gap at a genetic level, potentially impacting cognitive abilities.
  • Research highlights the link between Alzheimer's disease and insulin resistance, emphasizing the importance of brain energy metabolism.

Deep dives

Brain and Insulin Resistance

The brain requires a substantial amount of energy and relies on insulin for proper function. Insulin resistance in the brain leads to an energy gap at a genetic level, potentially impacting cognitive abilities. Research by Dr. Bickman and his team has highlighted the link between Alzheimer's disease and insulin resistance, indicating that Alzheimer's might be considered a metabolic issue. Studies have shown significant reductions in brain glucose use in individuals with conditions like polycystic ovary syndrome (PCOS), emphasizing the importance of brain energy metabolism.

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