#037 - James Clement: The Switch, Super Centenarians, Autophagy, Antioxidants, Fasting Vs. Feeding, AMPK vs. MTOR, Hacking Aging, And More!

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2:00 - Instagram Giveaway: Follow @MelanieAvalon And Comment Your Favorite Biohack To Enter To Win A Signed Copy Of The Switch!

2:25 - IF Biohackers: Intermittent Fasting + Real Foods + Life (Melanie Avalon)

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5:30 - James Unconventional History And Health Revolutions

9:40 - The Studies In Super Centenarians

14:15 - Genetic Mutations, Lifestyle Practices, And Environment For Longevity

21:30 - The Role Of Diet In Longevity

23:15 - The Changeability Of The Gut Microbiome

29:30 - What Is Autophagy And MTOR Why Is It Important For Longevity?

34:45 - Does Autophagy Require Lifestyle Intervention?

37:40 - The Different Routes To Autophagy, And Long Lived Populations Long Lived (Okinawa, Loma Linda, Mount Athos Monks)

42:00 - Modern Diets Like Carnivore, Elimination Diets, And The Role Of Protein In Longevity

46:30 - The Problem With HCHF

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49:30 - The Switch: MTOR, AMPK, And Autophagy

51:40 - Fasting And Calorie Restriction: Overlapping Or Additive?

55:00 - The Different Types of Autophagy

53:20 - Are The Benefits Of IF Just Due To Calorie Restriction Or Weight Loss?

56:20 - The Fasting Mimicking Diet 4:20

58:15 - Combating CR Effects With Exercise

1:01:20 - Fasting Forever And The Need For Cycling

1:03:00 - Daily Vs. Monthly Cycling And Genetic Expression

1:08:15 - Habitual Hunger, Energy Cues , And Retraining Cells With Keto Or Extended Fasts

1:11:30 -Carbs, Comfort Foods, Dopamine and Serotonin From The Gut

1:13:30 - AMPK Activators

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1:21:15 - Gluconeogenesis, Cortisol, Stress, And Blood Sugar

1:27:30 - Elevated Blood Sugar Levels On Low Carb, Elevated Blood Sugar, Aging , And Disease

1:30:20 - Endogenous Vs Exogenous Antioxidants, DNA Breaks, NAD, And The Dark Side To Antioxidants

1:38:25 - Antioxidants While Fasting

1:43:22 - NR and NMN Supplementation

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1:51:45 - The Hermetic Potential Of Low Dose Toxic Exposure

1:58:30 - Are We Programmed to Start Aging At 25?

2:06:30 - Instagram Giveaway: Follow @MelanieAvalon And Comment Your Favorite Biohack To Enter To Win A Signed Copy Of The Switch!