Critical Care Time 24. Thrombocytopenia with Dr. Matthew Rendo, MD.
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May 20, 2024 Dr. Matthew Rendo, a hematologist specializing in thrombocytopenia, discusses the importance of managing patients with low platelet count. Topics include causes of thrombocytopenia, platelet function, heparin-induced thrombocytopenia, diagnosing and treating thrombocytopenia, and platelet administration in severe cases.
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Platelet Basics
- Platelets are small cell fragments crucial for blood clotting, adhering to damaged blood vessels.
- Produced in bone marrow from megakaryocytes, which package organelles and granules within platelets.
Platelet Production Signal
- The liver produces thrombopoietin (TPO), which signals the production of megakaryocytes and subsequently platelets.
- This is analogous to erythropoietin (EPO) from the kidneys stimulating red blood cell production.
Thrombocytopenia Severity
- Thrombocytopenia severity is categorized as mild (100-150), moderate (50-100), and severe (<50 platelets).
- Disease context matters; in ITP, severe is <30.