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Amyloid Hypothesis
- The amyloid hypothesis suggests amyloid plaques are central to Alzheimer's, similar to cholesterol in heart disease.
- Genetics studies show mutations can increase or decrease amyloid processing and Alzheimer's risk.
Causation vs. Correlation
- Amyloid plaques are observed in Alzheimer's patients, but correlation doesn't equal causation.
- An underlying process could generate both amyloid and brain damage independently.
Aducanumab's Mixed Results
- Aducanumab, an anti-amyloid drug, showed mixed results in trials.
- The FDA granted accelerated approval despite an advisory committee's disapproval.