Barbell Medicine Podcast Bonus Episode: Can Your Cholesterol Be TOO Low? Why Starting is Hard, & Your Cardio Time-Hack
7 snips
Oct 16, 2025 This discussion dives into the hot topic of whether cholesterol can be too low, analyzing genetic data and clinical trials. The hosts unravel the notion of psychological inertia, exploring the dread of starting new tasks and offering practical tips to overcome it. They also tackle effective cardio strategies for those with busy schedules, emphasizing high-intensity workouts as the key to maximizing fitness in limited time. Tune in for insights that challenge common beliefs and provide actionable advice!
AI Snips
Chapters
Books
Transcript
Episode notes
ApoB As The True Risk Marker
- ApoB measures atherogenic particle count and tracks LDL-related cardiovascular risk.
- Lowering LDL reduces lifetime exposure and proportionally lowers atherosclerotic risk.
How Genetics Inform LDL Safety
- How low LDL is achieved matters: genetic PCSK9 loss-of-function increases clearance, lowering lifetime exposure.
- Lifetime low LDL from genetics shows dramatically lower atherosclerotic disease.
Trial Data Supports Ultra‑Low LDL
- Randomized trials mirror genetic findings: greater LDL lowering yields greater cardiovascular benefit.
- Benefits persist down to LDL <20 mg/dL with no clear increase in serious adverse events.
