Professor Robin Lovell-Badge discusses gene therapy breakthroughs for deafness, sickle cell disease, and immune deficiencies. Laura Wilcox explains the impact of volcanoes on weather. Physicist Martin Bencsik reveals how honeybees communicate through vibrations. Jim Al-Khalili talks about solar flares and Earth's protection.
Gene therapy can restore hearing by targeting specific tissue affected by deficient gene products.
Aerosols in the atmosphere impact weather by reducing solar radiation and influencing cloud formation.
Deep dives
Breakdown of Gene Therapy in Treating Genetic Diseases
Gene therapy involves correcting faulty genes to treat diseases. Genes are units in DNA that determine characteristics like blood type. Viral vectors are modified viruses used to deliver corrected genes into cells, either in vivo (directly to the patient) or ex vivo (treating cells outside the body). This method was successful in restoring hearing to a deaf girl by targeting specific tissue affected by the deficient gene product.
Challenges and Advancements in Gene Therapy
Gene therapy faces challenges like immune responses to viral vectors. Preclinical studies in animals and careful trials in patients are crucial. Various gene therapies are under development, such as treatment for sickle cell disease. Companies aim to balance costs, effectiveness, and accessibility of gene therapy for different diseases.
Understanding Effects of Aerosols on Weather Patterns
Aerosols are tiny particles suspended in the atmosphere, affecting local weather by reducing solar radiation and influencing cloud formation. Different aerosol sources include dust, sea salt, and man-made emissions. Regional aerosol effects have caused shifts in rainfall patterns globally. While aerosols have cooling effects, they also pose health and climate risks, warranting careful consideration in future climate models and policy decisions.
Last week, a girl who was born deaf had her hearing restored following gene therapy. In the US, the first commercial gene therapy for sickle cell disease has just begun. And Great Ormond Street Hospital has found great success in their trials and a gene therapy for children lacking an immune system. Gene therapy is clearly having a moment. But how do these groundbreaking therapies actually work? And will they ever be truly accessible to everyone? Geneticist Professor Robin Lovell-Badge answers all.
Also this week, atmospheric scientist Laura Wilcox answers an interesting listener question about the effect volcanoes can have on the weather and sticks around to dig into the connection between aerosols and weather in different regions.
The exhibition “Bees: A Story of Survival” opened at the World Museum in Liverpool this month. Part of the show explains the how honeybees communicate through vibration. Physicist Martin Bencsik, who collected and studies these vibrations, plays us a few and explains their meaning.
And did you get a chance to see the auroras that covered a large part of the Northern Hemisphere last weekend? The intense solar activity that caused them has some people alarm. Jim Al-Khalili, who has written a science fiction novel based on the concept, talks what is protecting us from solar flares and what could go wrong.
Presenter: Marnie Chesterton
Producers: Ella Hubber, Sophie Ormiston and Hannah Robins
Editor: Martin Smith
Production Co-ordinator: Jana Bennett-Holesworth
Get the Snipd podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share & Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode