
Ep 210 Decompensated Hypothyroidism Recognition and Management
Dec 16, 2025
In this insightful discussion, Dr. George Willis, an expert in endocrine emergencies from the University of Texas, and Dr. Alyssa Lewis, a critical care specialist from Toronto, dive into the intricacies of decompensated hypothyroidism. They clarify why 'myxedema coma' is a misleading term and discuss crucial ways to differentiate it from sepsis and overdose. Topics include the importance of cortisol testing, risks associated with intubation, and strategies for effective management, emphasizing the critical need for early diagnosis and proper treatment in these complex cases.
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Think Thyroid With Cold, Slow, Low Patients
- Consider decompensated hypothyroidism when hypotension, bradycardia, altered mental status and bradypnea coexist.
- Order thyroid tests and bundle cortisol early if the pattern fits.
Replace 'Myxedema Coma' With A Better Term
- Abandon the term "myxedema coma" because it misleads bedside recognition.
- Use "decompensated hypothyroidism" to capture varied presentations and end-organ dysfunction.
Bundle Tests When Suspecting Thyroid Crisis
- If you suspect a thyroid emergency, send TSH and free T4 and include a random cortisol and metabolic panel.
- Also get ECG, blood gas, cardiac enzymes, BNP and POCUS to guide management.
