The Optispan Podcast with Matt Kaeberlein

I Took 4 Different Biological Age Tests & Compared the Results... | 82

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Nov 21, 2024

Matt dives into the intriguing world of biological age testing by comparing results from different epigenetic kits. He explores the differences between biological and chronological age, revealing that the tests often provide inconsistent results. With skepticism at the forefront, he questions the accuracy and reliability of these popular kits. Marketing strategies of the companies are dissected, highlighting potential conflicts of interest. Ultimately, he offers a critical perspective on the true value of biological age testing in understanding health.

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INSIGHT

Epigenetic Changes and Aging

Epigenetic changes are one of the twelve hallmarks of aging, suggesting importance but not necessarily a primary driver.
These tests, at best, measure a part of biological aging, not the whole picture.

INSIGHT

Limitations of Epigenetic Clocks

Epigenetic clocks are correlations of correlations, linking methylation patterns with health outcomes and mortality.
They don't directly measure biological aging and lack mechanistic evidence connecting specific changes with aging.

ANECDOTE

Concerns about Direct-to-Consumer Tests

Matt Kaeberlein expresses concern about the direct-to-consumer epigenetic testing industry's lack of transparency and quality control.
He questions if companies are using good laboratory practices and if the tests truly measure what they claim.

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Subscribe to our channel: https://www.youtube.com/@optispan Related Episode(s):Biological Age & what it REALLY means | 9 - Longevity Science #3: https://youtu.be/DcxgEwQKx8Q?si=y1iF4RviJc0n__gW In this deep dive, Matt examines the growing trend of direct-to-consumer biological (epigenetic) age testing kits, exploring their purpose, popularity, and limitations. He outlines his experimental design to evaluate the accuracy and precision of these tests, addressing important questions about what they truly measure and how reliable they are. Matt unpacks the difference between biological and chronological age, discusses the co-marketing strategies employed by these companies, and reflects on his own results to provide a critical perspective on the value of these kits. 0:00 Introduction 2:17 Experimental Design 3:03 Key Questions 5:15 Marketing Strategies of Bio-Age Companies 6:15 Biological Age vs. Chronological Age 6:49 Measuring Biological Age 8:32 Limitations of Epigenetic Clocks 13:23 Accuracy and Precision 15:49 Data Analysis 19:22 Matt’s Biological Age Results 22:53 Key Takeaways 24:50 Sanity Checks 31:58 Conclusions Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!