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EMCrit Podcast
EMCrit 354 - Reduced-Dose Systemic Peripheral Fibrinolysis in Massive Pulmonary Embolism
Jul 30, 2023
Exploration of reduced-dose fibrinolysis in massive pulmonary embolism, debate on optimal dosing, challenges in publishing device therapy trials, intricacies of balancing TPA and Heparin therapies, personalized dosing for improved outcomes.
35:51
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Quick takeaways
- Personalized dosing of TPA for massive PE improves outcomes with reduced bleeding risks.
- Optimizing heparin therapy post-TPA infusion in acute PE management requires customized protocols.
Deep dives
Exploring Treatment Options for Massive Pulmonary Embolism
Treating patients with massive pulmonary embolism often involves the dilemma of deciding on thrombolytic therapy dosing. The podcast discusses the shift towards lower doses of TPA for these patients, aiming to balance effectiveness with reduced bleeding risk. By exploring a pilot study involving 25 milligrams of TPA over six hours for massive PE patients, the podcast highlights the potential game-changing impact of personalized dosing strategies for critical care patients.
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Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode