Oncotarget
Oncotarget’s Top-10 Most-Viewed Papers in 2021
Jan 21, 2022
Explore the top 10 most-viewed oncology papers of 2021, covering topics like metformin and berberine for metabolic diseases, SARS-CoV-2 spike protein link to COVID-19 complications, physical activity's impact on telomere length, and the role of hedgehog signaling in gastric cancer. Dive into cancer therapy, gerostatics, melatonin's effect on prostate cancer, challenges of early pancreatic cancer detection, and inflammatory responses in organs.
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Quick takeaways
- Metformin and Berberine are versatile drugs for treating common metabolic diseases due to their activation of different pathways like AMPK and historical medicinal use.
- Cell fusion mediated by the SARS-CoV-2 spike protein plays a crucial role in COVID-19 complications and vaccine side effects, highlighting the importance of understanding viral mechanisms for prevention.
Deep dives
Metformin and Berberin in Treating Metabolic Diseases
Metformin, a drug used for lowering glucose levels, and Berberin, an extract from Berberis vulgaris L-root, have drawn attention for their potential in treating common metabolic diseases such as type 2 diabetes and diarrhea. Metformin's activation of AMP-activated protein kinase and Berberin's historical use as an herbal medicine highlight their versatility in medical applications.
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