PsychRounds: The Psychiatry Podcast

[SSRIS] Selective Serotonin Reuptake Inhibitors - A Brief Discussion

45 snips
Dec 2, 2023
The discussion dives into the history of SSRIs, tracing their roots back to the monoamine hypothesis. It explores how these medications evolved from earlier antidepressants like MAOIs, illuminating their impact on mental health treatment. The relationship between SSRIs and gut health is analyzed, highlighting significant side effects. There's a focus on weight gain and bleeding risks associated with these medications, especially in older patients. Finally, the complexities of prescribing SSRIs for bipolar disorder are examined, questioning the traditional views on chemical imbalances.
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INSIGHT

Monoamine Hypothesis Origin

  • Modern antidepressants originated from the observation that reserpine, a VMAT2 inhibitor, caused depressive symptoms.
  • This led to the monoamine hypothesis and the development of MAOIs and TCAs.
INSIGHT

SSRI Development

  • Early antidepressants like MAOIs and TCAs, while effective, had significant side effects.
  • This prompted the development of SSRIs, starting with fluoxetine (Prozac) in 1987.
ANECDOTE

Zimelidine

  • Zimelidine, released in Europe in 1982, was the first SSRI.
  • It caused weight loss and had no sexual side effects, but was discontinued due to rare cases of Guillain-Barre syndrome.
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