PsychRounds: The Psychiatry Podcast [SSRI] - Fluvoxamine (Luvox) & Paroxetine (Paxil)
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Dec 4, 2023 The discussion dives into the pharmacokinetics of paroxetine, highlighting its short half-life and the challenges of discontinuation syndrome. It explores the calming effects of Paxil, particularly for anxiety disorders, while addressing safety during pregnancy. The role of paroxetine in managing menopause symptoms, like hot flashes, is also examined. Additionally, the unique application of fluvoxamine for OCD treatment is analyzed, comparing its effectiveness and side effects against other SSRIs, and emphasizing dosing strategies for better patient outcomes.
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Paroxetine for Anxious Distress
- Consider paroxetine (Paxil) for patients who have failed multiple SSRIs and exhibit anxious distress.
- Be mindful of its potential side effects and the availability of other options.
Paroxetine Side Effects
- Paroxetine (Paxil) is associated with several side effects, including discontinuation syndrome, anticholinergic effects, and sexual dysfunction.
- It is also a potent inhibitor of CYP2D6, increasing the risk of drug interactions.
Paroxetine for Menopausal Symptoms
- Paroxetine, branded as Brisdelle, is approved for vasomotor symptoms associated with menopause.
- Other SSRIs or SNRIs like venlafaxine might be preferred due to paroxetine's side effect profile.