Bloody Minded Episode 56 - Lymph and Let Die | Approach to Lymphocytosis
Aug 5, 2025
In this insightful discussion, Lise Kempler, a hematology registrar at St. Vincent's in Sydney, dives deep into the world of lymphocytosis. She explains the vital roles of lymphocytes as the immune system's 'marathon runners' and discusses the complexities behind elevated lymphocyte counts. Topics range from the infectious causes of lymphocytosis, including the notorious Epstein-Barr Virus, to diagnostic techniques like flow cytometry. Case studies highlight real-life connections between lymphocytosis and autoimmune diseases, enriching the dialogue with medical insight and humor.
AI Snips
Chapters
Transcript
Episode notes
Lymphocytes Are Immune Marathoners
- Lymphocytes are like immune system marathon runners with endurance and memory.
- They provide strategic, long-lasting immunity by remembering past infections for faster response.
Approach Lymphocytosis Methodically
- To approach lymphocytosis, start with thorough patient history and physical exam.
- Look for infectious symptoms, autoimmune signs, B symptoms, and consider acute vs chronic timing.
Use Blood Film and Flow Cytometry
- Always review blood film morphology to assess if lymphocytes look normal or atypical.
- Use flow cytometry to test clonality and differentiate malignant from reactive lymphocytosis.