JAMA Editors' Summary From AHA: Coffee Consumption and Atrial Fibrillation, DASH-Patterned Groceries and Effects on Blood Pressure, Oral PCSK9 Inhibitor Enlicitide for Heterozygous Familial Hypercholesterolemia, and more
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Nov 9, 2025 Discover how caffeinated coffee might reduce atrial fibrillation recurrence, based on a compelling randomized trial. Dive into the efficacy of an oral PCSK9 inhibitor that significantly lowers LDL cholesterol levels. Learn about DASH-patterned groceries and their surprising effects on blood pressure in low-income communities. Uncover insights from the UK Biobank linking physical activity to better cardiovascular outcomes in cardiomyopathy variant carriers. Plus, explore the implications of clonal hematopoiesis for heart failure risk.
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Coffee Linked To Lower AF Recurrence
- Randomized trial DCAF found daily caffeinated coffee reduced AF/flutter recurrence compared with abstinence over six months.
- The result contradicts common belief and highlights trial evidence over anecdotes.
Oral PCSK9 Cuts LDL Substantially
- Oral PCSK9 inhibitor enlicitide reduced LDL cholesterol by about 60% versus placebo at 24 weeks in heterozygous familial hypercholesterolemia.
- The oral route may improve uptake compared with injectable monoclonal antibodies.
Exercise Benefits Genotype-Positive Carriers
- Among genotype-positive but phenotype-negative cardiomyopathy variant carriers, higher moderate-to-vigorous activity linked to fewer cardiovascular events.
- Benefits paralleled those seen in noncarriers, supporting guideline activity recommendations.