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806. GLP-1 Explained: The Gut’s Secret to Controlling Sugar Cravings

Oct 16, 2025
Dr. Colleen Cutcliffe, CEO and Co-Founder of Pendulum, dives into the intersection of gut health and metabolism. She explains the critical role of GLP-1 in managing sugar cravings and reveals groundbreaking probiotic solutions for unlocking metabolic potential. Listeners discover the gut-brain connection, the benefits of fiber and polyphenols, and how certain gut microbes, like Akkermansia, boost natural GLP-1 production. Personal transformation stories and practical tips on continuous glucose monitoring add a layer of hope for those battling emotional eating.
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INSIGHT

How GLP-1 Drugs Work And Their Tradeoffs

  • GLP-1 drugs mimic the body's natural GLP-1 hormone to suppress appetite and improve sugar metabolism.
  • Drugs keep GLP-1 high continuously, which gives quick hunger control but risks receptor "deafness" and rebound when stopped.
INSIGHT

Teach Your Body To Produce GLP-1

  • Stimulating natural GLP-1 teaches the body to regulate hunger and insulin cyclically.
  • That approach takes longer but creates lasting metabolic regulation versus continuous drug signaling.
ADVICE

Feed Your Microbiome With Fiber And Polyphenols

  • Eat diverse fiber-rich vegetables and legumes to feed beneficial microbes.
  • Add polyphenol sources like berries, green tea, dark chocolate, and pomegranate to support microbiome function.
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