The Funk'tional Nutrition Podcast

Detox or Re-Tox? Why Beta Glucuronidase Can Block Hormone & Toxin Clearance | Ep 381

10 snips
Oct 14, 2025
Explore the intriguing world of beta glucuronidase, a gut enzyme that can sabotage detoxification by allowing toxins and hormones to re-enter your system. Learn how low-fiber diets and constipation elevate its levels, leading to symptoms of estrogen dominance like bloating and mood swings. Discover short-term solutions, such as calcium D-glucarate, and the importance of long-term microbiome restoration. Erin emphasizes the need to harmonize gut, liver, and hormone health for effective detoxification strategies.
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INSIGHT

How Glucuronidation Enables Safe Excretion

  • Glucuronidation in the liver binds toxins and hormones to glucuronic acid so they can be excreted safely via bile and stool.
  • Beta-glucuronidase from gut bacteria can undo this binding and allow reabsorption of those compounds.
INSIGHT

Beta-Glucuronidase Reverses Liver Detox

  • Beta-glucuronidase is a bacterial enzyme that deconjugates glucuronidated compounds in the gut, freeing hormones and toxins for reabsorption.
  • This deconjugation reverses the liver's phase two detox work and undermines elimination.
ANECDOTE

Gummies: Ridiculed Yet Practically Useful

  • Erin humorously criticized the gummy supplement trend but admitted her husband reliably takes gummy supplements daily.
  • She regularly takes Organifi Happy Drops and notices mood benefits from ingredients like saffron and passionflower.
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