In this discussion, Jean-Marie Perrone, an emergency medicine physician specializing in opioid addiction, and Stephen Lloyd, an advocate for medication-assisted treatment, delve into the complexities of the opioid crisis. They highlight how effective treatments like buprenorphine remain underutilized due to stigma and strict regulations. Personal stories illustrate the urgent need for harm reduction strategies. The conversation challenges traditional views of abstinence, advocating for a more compassionate and evidence-based approach to treatment and recovery.