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VJHemOnc Podcast

iwNHL 2023 Session IV: Novel therapies in NHL: BTK inhibitors, BTK degraders, and bispecific antibodies

Dec 1, 2023
Tanya Siddiqi and Nirav Shah discuss the role of BTK inhibitors and degraders in NHL. They also explore the growing role of bispecific antibodies in this disease setting. Topics include novel therapies, Perdibrutnib as a non-covalent inhibitor, lessons from a first-in-class bispecific therapy, potential of Biennium-2-M-Amp in DLBCL, and Phase 2 trial findings of Audra Nextermat and Plimotumab.
15:34

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Quick takeaways

  • BTK inhibitors and degraders show promise in treating lymphoma, especially in patients who have failed previous therapies or have specific mutations.
  • Bi-specific antibodies have a growing role in non-Hodgkin lymphomas, with potential for use in various indications and combinations.

Deep dives

Growing Role of BTK Inhibitors and Degraders in Lymphoma

In this podcast episode, Tanya Sadiqi and Nirav Shah discuss the growing role of BTK inhibitors and degraders in lymphoma. They highlight the efficacy of Perdibrutnib, a non-covalent BTK inhibitor, in patients who have progressed on covalent inhibitors or have mutations at the C-481 site. They also discuss the potential of BTK degraders in treating patients who have failed BTK inhibitor therapy, including those with double-class exposure. The podcast emphasizes the need for further development and sequencing of these therapies to address resistance and enhance patient response.

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