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In this podcast episode, Tanya Sadiqi and Nirav Shah discuss the growing role of BTK inhibitors and degraders in lymphoma. They highlight the efficacy of Perdibrutnib, a non-covalent BTK inhibitor, in patients who have progressed on covalent inhibitors or have mutations at the C-481 site. They also discuss the potential of BTK degraders in treating patients who have failed BTK inhibitor therapy, including those with double-class exposure. The podcast emphasizes the need for further development and sequencing of these therapies to address resistance and enhance patient response.