The Hunter Williams Podcast Peptide Replacement Therapy | The Future of Anti-Aging Medicine
Oct 31, 2025
Dive into the fascinating world of peptide replacement therapy! Discover how replacing declining endogenous peptides can boost energy, muscle health, and immunity as we age. Learn about 14 crucial peptides, like IGF-1 for muscle maintenance and Thymosin Alpha-1 for immune support. Hear about the remarkable benefits of peptides like Humanin and Glutathione for brain health and detoxification. Explore how these advancements could revolutionize anti-aging medicine and enhance our healthspan.
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IGF-1 Declines And Muscle Health
- IGF-1 produced by the liver declines ~40–50% by age 20 and ~50% lower by age 60 compared to the 20s.
- Restoring IGF-1 (via GH, secretagogues, or IGF-1 analogs) can combat sarcopenia but requires cautious dosing.
Thymosin Alpha-1 Reverses Immunosenescence
- Thymosin alpha-1 is a 28-amino-acid thymic peptide that promotes T-cell maturation and immune function.
- Levels decline from childhood and by age 50 thymic hormones plummet, so TA1 can reverse aspects of immunosenescence.
Use TB500 For Tissue Repair
- Use TB500 (thymosin beta-4 fragment) for tissue repair, angiogenesis, and reducing inflammation after injury.
- Consider cyclic or targeted use for tendon, cardiac, eye, and kidney repair as thymic peptide output declines with age.