Two Onc Docs Metastatic Colon Cancer 2025 UPDATE
Mar 11, 2025
Discover the latest breakthroughs in treating metastatic colon cancer. The discussions highlight advances in personalized therapies and the significance of molecular testing. Listeners will learn about effective chemotherapy regimens and the potential of targeted therapies to enhance survival outcomes. The insights shared promise to equip patients and caregivers with essential knowledge in a continually evolving field.
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5-FU Toxicity and DPD Deficiency
- Remember DPD deficiency, an autosomal recessive condition leading to severe toxicity with 5-FU.
- Treat this toxicity with uridine triacetate, a competitive inhibitor of 5-FU.
Capecitabine Toxicities
- Be aware of hand-foot syndrome, mucositis, skin changes, and GI symptoms with oral capecitabine.
- Avoid capecitabine if creatinine clearance is less than 30.
Oxaloplatin Toxicities
- Oxaloplatin causes cold sensitivity and neuropathy, so advise patients about cold sensations in fingertips, toes, mouth, and esophagus.
- Reduce the dose if creatinine clearance is less than 30, and watch for peripheral neuropathy after repeated doses.