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Histamine intolerance affects a significant portion of the population, particularly those with digestive issues. It can manifest through various symptoms, including digestive discomfort, neurological disturbances, skin reactions, respiratory issues, and cardiovascular effects. A healthy gut plays a crucial role in managing histamine levels, as a damaged gut lining can lead to increased histamine production and decreased enzyme activity necessary for histamine breakdown. Factors such as fungal and bacterial overgrowth can exacerbate histamine intolerance, highlighting the importance of gut health in mitigating these symptoms.