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Flex Diet Podcast

Episode 321: Optimizing Fat Loss and Muscle with Dr. Mike Ormsbee

Apr 28, 2025
57:58

Welcome back to the Flex Diet Podcast. I’m Dr. Mike T. Nelson, and today I’m joined by my good friend and colleague, Dr. Mike Ormsbee. We’re digging deep into how to optimize metabolism using strategies from the Flex Diet Certification, as well as why both aerobic and resistance training are crucial for long-term success.

We also delve into some advanced topics, such as how growth hormone and lipolysis contribute to effective fat utilization, and how cutting-edge techniques like microdialysis enable us to study metabolism at a local level. Along the way, we hit on key concepts like fat metabolism, body composition changes, and even how evening eating affects the process.

We’ll share insights from some of the studies we’re working on now, and why combining resistance training with smart nutrition could be the game-changer you’re looking for. Hope you enjoy this deep dive into the science (and practice) of fitness and health!

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Episode Chapters:

  • 03:07 Informal Conversation Kickoff
  • 05:22 Academia and Personal Branding
  • 07:08 Cardio for Meatheads
  • 09:01 Resistance Training and Fat Metabolism
  • 17:26 Body Composition Studies
  • 27:02 Obesity and Exercise Response
  • 29:04 Exploring Alpha Receptors and Him Buying
  • 29:32 Resistance Training and Obesity
  • 30:33 Growth Hormone and Insulin Responses
  • 31:23 Body Fat and Athletic Performance
  • 32:00 Triathletes and Body Fat Analysis
  • 32:52 Resistance Training vs. Aerobic Training
  • 33:07 NIH Grant and Current Study
  • 33:28 Lipolysis and Fat Loss Mechanisms
  • 35:43 Muscle and Fat Tissue Communication
  • 37:35 Resistance Training and Fat Loss
  • 43:11 Eating in the Evening: Myths and Facts
  • 46:23 Protein Intake and Sleep
  • 51:00 Future Research Directions
  • 52:45 Conclusion and Final Thoughts.

Flex Diet Podcast Episodes You May Enjoy: 

  •  Episode 209: How to achieve your fat loss goals while not overly restrictive: an interview with the author of “You Can’t Screw This Up,” Adam Bornstein
  • Episode 173: High-Level Nutrition and Programming for Fat Loss: Dr. Pat Davidson with Dr. Mike T Nelson

Connect with Dr. Ormsbee: 

Get In Touch with Dr Mike:

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