The Curbsiders Internal Medicine Podcast #258 Nephrotic Syndrome, Smoking Cessation, Prev Med Update (TFTC #2)
Feb 24, 2021
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Proteinuria Workup Guidance
- Use urine dipstick to detect albumin and quantify proteinuria with albumin-creatinine or protein-creatinine ratios.
- Pursue further workup and consider biopsy if proteinuria exceeds 2 grams or causes acute kidney injury.
Anti-PLA2R Importance in Nephropathy
- Anti-PLA2R antibodies are a key marker for primary membranous nephropathy.
- Monitoring their titers helps assess disease activity and guide treatment response.
Anticoagulation in Nephrotic Syndrome
- Consider prophylactic anticoagulation in nephrotic syndrome when albumin is below 2.5 and other risk factors exist.
- Use the GN Tools calculator to weigh bleeding risk versus benefit before starting anticoagulation.