PsychRounds: The Psychiatry Podcast The Antipsychotics: Haloperidol (Haldol)
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Aug 28, 2024 Delve into the historical roots of Haloperidol, one of the most widely used first-generation antipsychotics. Discover its unique mechanism as a D2 receptor antagonist and explore its effective applications for psychotic disorders and Tourette's. Learn about various formulations and dosing strategies, including transitioning from oral to long-acting injectables. Critical discussions on the efficacy in managing acute mania and the potential risks, especially for those with renal issues, showcase its complex yet vital role in psychiatric care.
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Haloperidol Overview
- Haloperidol (Haldol) is the most commonly used first-generation antipsychotic.
- This podcast discusses it in a series about antipsychotics, starting with typicals before atypicals.
Haloperidol History
- Haloperidol was discovered by Paul Janssen, founder of Janssen Pharmaceuticals.
- Clinical trials began in 1958, with approval in Belgium in 1959 and FDA approval in 1967.
Haloperidol Chemical Class and Indications
- Haloperidol is a butyrophenone, unlike phenothiazines.
- It is indicated for psychotic disorders, Tourette's, severe behavioral problems in children, and short-term hyperactivity treatment.