Mastering Nutrition

Startled?! Try Glycine!

10 snips
Oct 28, 2023
An exploration of the startle reflex and its underlying conditions, the dominant role of glycine neurotransmission in hyper-eplexia, treatment options and nutritional strategies for glycine neurotransmission disorders, factors leading to glycine loss in urine and strategies to increase glycine intake, and the therapeutic use and potential risks of glycine.
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INSIGHT

Distinct Neural Control Of Startle

  • The startle reflex integrates sensory input in the brainstem and motor output in the spinal cord, driven by glutamate activation.
  • GABA inhibits the brainstem component while glycine inhibits spinal motor coordination, explaining different regulatory points.
INSIGHT

Glycine Dominates Severe Startle Disorders

  • Every known genetic cause of hyperekplexia involves glycine neurotransmission, highlighting glycine's dominant role in extreme startle disorders.
  • This pattern suggests glycine dysfunction can produce a spectrum of exaggerated startle and muscle tension.
ADVICE

Check Glycine If Startle Is Excessive

  • If you have an exaggerated startle reflex, consider assessing and addressing glycine status before other interventions.
  • Talk with a medical professional before changing glycine intake or trying supplements.
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