#73: PUFA is Estrogenic | Endotoxin, Cancer, and Inflammation | Serotonin Causes Digestive Disease? with Georgi Dinkov
Nov 15, 2021
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Georgi Dinkov, a health researcher and podcaster, discusses various topics including the link between low testosterone/high estrogen and COVID-19 mortality, the effects of vitamin D3 on muscle/thymus, endotoxin's role in cancerization, placebo effect's impact on anxiety, omega-3's risk for atrial fibrillation, the estrogenic nature of PUFA, the potential harm of serotonin and SSRI drugs, the curative effects of restoring oxidative metabolism in cancer, and updates on Idealabs products.
High intake of omega-3 fatty acids is associated with an increased risk of atrial fibrillation.
Chronic low-grade inflammation caused by endotoxemia can contribute to the development of cancer.
Selective serotonin reuptake inhibitors (SSRIs) may work by raising dopamine levels, not serotonin, for their antidepressant effects.
Deep dives
Omega-3 intake linked to increased risk of atrial fibrillation
A new study found that a high intake of omega-3 fatty acids is strongly correlated with an increased risk of developing atrial fibrillation. This contradicts the common belief that omega-3s are beneficial for cardiovascular health. The study showed that the effect is dose-dependent, meaning that the more fatty fish consumed, the higher the risk. Omega-3s have been touted for their anti-inflammatory properties, but this study suggests that the inflammatory effects of omega-3s may outweigh any potential benefits. It is important to consider the source of information and critically evaluate the evidence when it comes to dietary recommendations.
Low-dose endotoxemia shown to be a risk factor for carcinogenesis
A study found that low-grade endotoxemia, a chronic low-grade inflammatory response, is a significant risk factor for the development of cancer. The study demonstrated that low levels of endotoxin in the bloodstream can contribute to the formation of established tumors. This highlights the importance of addressing chronic inflammation to reduce the risk of cancer. It is crucial to consider both dietary and environmental factors that can contribute to endotoxemia and inflammation in the body.
SSRIs increase dopamine, not serotonin
A study challenges the common belief that selective serotonin reuptake inhibitors (SSRIs) work by increasing serotonin levels in the brain. Instead, the study found that SSRIs raise dopamine levels, suggesting that the increased dopamine may be responsible for the antidepressant effects. The study also raises the question of whether being honest with patients and treating them with respect could be a contributing factor to their improvement. This highlights the need for further research and a critical evaluation of the mechanisms of action of SSRIs.
Estrogen therapy for menopause is making a comeback
Estrogen therapy for menopause or pre-menopausal women is gaining popularity again, despite previous studies showing its association with carcinogenic and cardiovascular risks. The largest hormonal study, the Women's Health Initiative Study, showed conclusive evidence of these risks, but it seems to have become old news, as estrogen therapy is being used again. However, it is important to note that excessive unsaturated fats in cells can lead to disruptions in water regulation and damage to respiration, resulting in toxic byproducts that pose a threat to cells.
Serotonin and its role in digestive issues and cancer
Serotonin plays a crucial role in gastrointestinal function and is often involved in digestive issues. Some gastrointestinal specialists believe that serotonin in the gut is beneficial, but the fact that anti-serotonin drugs like Zelnorm, a serotonin agonist, caused severe side effects and were eventually withdrawn from the market raises questions about this belief. Recent studies suggest that high serotonin levels in the gut can trigger flare-ups of conditions like Crohn's disease and can even contribute to the development of inflammatory bowel disease. Stress, certain foods, fasting, and mechanical injuries can all elevate serotonin levels, leading to various health problems. Additionally, interventions that target oxidative phosphorylation and regulate serotonin production may hold promise in cancer therapy.
