MDS Podcast Immune, metabolic and tau markers in blood cells in progressive supranuclear palsy
Feb 24, 2025
Tommaso Schirinzi, a neurologist at Tor Vergata University of Rome, discusses groundbreaking research on immune and metabolic markers in blood cells related to progressive supranuclear palsy (PSP). He reveals insights about the role of neuroinflammation in PSP and compares it with other neurodegenerative diseases. The conversation highlights elevated immune response indicators, the significance of mitochondrial bioenergetics, and the implications of phosphorylated tau proteins as potential biomarkers for treatment development. Future research directions stress the need for collaboration to explore these complex relationships further.
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Neuroinflammation in Neurodegenerative Diseases
- Neuroinflammation is increasingly implicated in neurodegenerative diseases like Alzheimer's, Parkinson's, and PSP.
- Studies show immune cell infiltration in the brain and altered immune markers in bodily fluids.
Systemic Inflammation in PSP
- A study found increased white blood cell and neutrophil counts in PSP patients compared to controls.
- This suggests systemic inflammation in PSP, measured by a higher neutrophil-to-lymphocyte ratio.
Immunometabolic Signature in PSP
- Leukocytes in PSP patients show increased oxygen consumption, indicating a hypermetabolic state.
- This likely reflects increased energy demand to sustain inflammation, supported by NRF2 pathway activation.