MDS Podcast

In this episode, we explore the role of genetics and genetic testing in the decision-making and outcome of deep brain stimulation in Parkinson's disease with two experts in the field: Dr. David Arkadir and Dr. Saar Anis. This interview is also available in the text format within the MDS Scientific Issues: Read the issue

Mark Edwards, a Professor of Neurology at King’s College London, specializes in functional movement disorders and dystonia. He discusses the historical evolution of propriospinal myoclonus, shedding light on its non-structural origins. The conversation highlights key assessment strategies for symptoms, with an emphasis on identifying red flags. Additionally, they explore the complex diagnostic process and the variety of treatment options available, underlining the importance of tailoring approaches to each patient's context.

Dr. Sarah Camargos chats with Prof. Laura Bannach Jardim, a prominent Neurology Professor at the Federal University of Rio Grande do Sul, known for her expertise in neurogenetic diseases. They delve into how rural living impacts the onset of Machado-Joseph disease, revealing surprising connections between environmental factors and health. The discussion touches on the genetic roots of the disease, the need for confirmatory research in diverse populations, and highlights the healthcare inequalities faced by affected families in Brazil.

Prof. Marina de Koning-Tijssen interviews Dr. Christos Ganos on the differential diagnosis of myoclonus. Dr. Ganos explains how he distinguishes between jerky movements based on clinical history and examination, and discusses the differential diagnosis across various parts of the body.

Dr. Hugo Morales Briceno interviews Prof. David Devos from the University of Lille, France, about the results of the phase 1/2 clinical trial using intracerebroventricular anaerobic dopamine in Parkinson’s disease with L-dopa-related complications. Read the article.

Prof. Marina de Koning-Tijssen interviews Professors Anna Latorre and Shabbir Merchant on the topic of electrophysiology, with a focus on cortical myoclonus. Together they discuss the potential applications of electrophysiology for myoclonus in clinical practice. They also explore the complex interface between cortical myoclonus and epilepsy.

Dr. Michele Matarazzo interviews Prof. Irena Rektorová about her recent study on early changes in the locus coeruleus in mild cognitive impairment with Lewy bodies. Using neuromelanin-sensitive MRI, the study reveals selective vulnerability of the caudal locus coeruleus and its association with specific cognitive and other nonmotor features. The conversation explores the implications for early diagnosis, the “body-first” hypothesis, and the potential role of NM-MRI as a biomarker. Read the article.

Prof. Marina de Koning-Tijssen interviews Prof. John Caviness on the topic of myoclonus, focusing on its new classification and treatment. They discuss the long-awaited recently published classification of myoclonus and explore the latest treatment options.

On this special World Parkinson’s Day episode, Dr. Michele Matarazzo is joined by John Dean—speech-language pathologist and Chair of the MDS Allied Health Professionals Group—to explore the essential roles of care partners, allied health professionals, and the broader Parkinson’s community. From physiotherapists to family members, we shine a light on the many people who support those living with Parkinson’s disease every day. World Parkinson's Day

Dr. Sara Schaefer discusses with Dr. Michelle Fullard the similarities and differences in how men and women with Parkinson's disease approach the decision of whether or not to undergo deep brain stimulation. Read the article.