The Gist The Bliss Gene And The Burden Of Mood
7 snips
Jul 22, 2025 Richard A. Friedman, a prominent psychiatrist and director at NYU's Psychopharmacology Clinic, dives into the fascinating world of anandamide, dubbed the 'bliss molecule.' He explains how a genetic mutation can lead to reduced anxiety and drug cravings, shedding light on our emotional resilience. The discussion also touches on the role of brain chemistry in personal relationships and leadership challenges. Additionally, the politics of sanctuary cities and a burial standoff of a former Zambian president add intriguing layers to the conversation.
AI Snips
Chapters
Transcript
Episode notes
Mike Pesca's Anandamide Discovery
- Mike Pesca reacted strongly to Richard Friedman's article on the 'feel good gene' called anandamide.
- This inspired him to explore the science behind his positive mood disposition.
Anandamide and Mood Control
- Anandamide is a natural cannabinoid in the brain regulating mood, anxiety, and appetite.
- People with higher anandamide levels tend to have lower anxiety and less drug craving.
FAAH Enzyme Controls Anandamide
- The FAAH enzyme degrades anandamide, controlling its brain levels.
- A loss-of-function mutation in FAAH leads to elevated anandamide and lower anxiety.