Can AKG Make You Anxious?: The Pros & Cons of This Longevity Supplement
May 3, 2024
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Discover the risks and rewards of megadosing AKG for longevity, including enhanced anxiety and sleep issues. Learn about AKG's conversion into glutamate and counteracting strategies with supplements. Dive into the pros and cons of AKG supplementation and its potential benefits for optimal health outcomes.
Mega-dosing AKG can lead to increased anxiety and sleep issues, highlighting the risks of high intake.
Supplementing with B6, niacin, and NAC can help counteract elevated glutamate levels caused by AKG, promoting better mental health.
Deep dives
Side Effects of Mega-Dosing AKG
Mega-dosing AKG, also known as alpha-ketoglutarate, significantly affected the speaker's body, causing various side effects. The speaker experimented with much higher dosages of AKG than usual, up to 15 times the normal amount, to observe its impact. The main reasons for taking AKG included longevity benefits, muscle recovery, energy, nitric oxide production, and detoxification. However, mega-dosing led to increased anxiety, glutamate levels, looped thoughts, decision-making difficulties, reduced stress tolerance, nail-biting, and insomnia.
Link Between AKG and Glutamate Levels
The speaker's heightened glutamate levels due to mega-dosing AKG highlighted the conversion pathway of AKG to glutamate in the body. The speaker explored how different genetic variations and predispositions can influence individual responses to AKG consumption. High glutamate levels induced by AKG led to specific symptoms such as anxiety, stress intolerance, and fragmented sleep. Strategies such as taking B6, niacin, and NAC were employed to counteract the glutamate increase.
Approach to Lowering Glutamate Levels
To address the elevated glutamate levels caused by AKG, the speaker experimented with various supplements and techniques to reduce glutamate and enhance well-being. B6, niacin, and NAC were found to be effective in managing glutamate levels and alleviating symptoms like anxiety and stress. Additionally, serotonin-boosting supplements like passionflower and strategies that target GABA activation were beneficial in restoring balance and reducing anxiety. The combination of these approaches successfully normalized glutamate levels and improved overall focus and mental health.
In this episode, Joe dives deep into the effects of megadosing AKG (Alpha Ketoglutarate), a crucial supplement in metabolic pathways and its implications for longevity. Discover the risks and rewards as Joe recounts increasing his AKG intake to 15 times the standard dosage, leading to notable side effects such as enhanced anxiety and sleep issues.
Joe meticulously explains the biochemical transformation of AKG into glutamate and reviews strategies to counteract these negative impacts, including the use of supplements like B6 and Niacin.
He concludes by weighing the pros and cons of AKG.
Tune in to learn more about AKG supplementation, its potential benefits, and how to safely navigate its use for optimal health outcomes
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