

2652: Reversing Gray Hair & Skin Age by 20+ Years with Yamanaka Gene Therapy Factors (TT)
May 11, 2023
Discover the groundbreaking research on gene therapy and its potential to reverse aging signs like gray hair and skin damage. Exciting studies from the Salk Institute reveal how Yamanaka factors have produced remarkable results in mice, hinting at a healthier lifespan for humans soon. The talk also explores the innovative role of stem cells in rejuvenating bodily functions, opening up a fascinating conversation on the future of anti-aging treatments and the science behind them.
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Gene Therapy Reverses Aging
- Intermittent expression of genes tied to embryonic states can reverse aging signs like gray hair and skin aging by 20+ years.
- Treated mice showed increased lifespan by 30%, implying human life extension by two decades or more is possible.
Age Factor in Reversal Effectiveness
- Starting treatment at middle-age yields significant age reversal; older subjects show limited effects from short treatment.
- Age reversal therapy takes longer for older individuals, suggesting prolonged treatment is necessary for best results.
Three Yamanaka Factors Work Best
- Using three of the four Yamanaka gene factors achieves better age reversal results than using all four together.
- The four master genes are OCT4, SOX2, KLF4, and CMYC, central to cellular reprogramming.