Neurology® Podcast
Understanding Apathy in Parkinson Disease
Jul 18, 2024
Dr. Campbell Le Heron discusses the association of clinical and neurocognitive factors with apathy in Parkinson disease. They explore the complexities of apathy beyond dopamine deficiencies, the importance of early detection, and the impact of apathy on mortality. Counseling strategies and treatment options are also highlighted.
18:39
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Quick takeaways
- Apathy in Parkinson's disease involves disruptions in the brain's reward network and effort-based decision-making.
- Depressive symptoms, lower cognition, and higher motor severity predict the development of apathy in Parkinson's disease patients.
Deep dives
Definition and Impact of Apathy in Parkinson's Disease
Apathy in Parkinson's disease is characterized by a reduction in motivation and goal-directed behavior, affecting various aspects of patients' lives. While initially thought to be solely linked to dopamine deficiency, apathy's underlying mechanisms involve disruptions in the brain's reward network and effort-based decision-making. The presence of apathy significantly increases the risk of mortality in patients with Parkinson's disease, highlighting its impact on health outcomes.
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