Could A Fungal Pandemic Be “The Last of Us?", with Arturo Casadevall
Jan 9, 2025
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Arturo Casadevall, a microbiology professor at Johns Hopkins, warns of a looming fungal pandemic similar to the one in 'The Last of Us.' He discusses how climate change is enabling fungi to adapt and resist treatments, posing a serious public health threat. Casadevall emphasizes the need for preparedness through awareness, vaccines, and innovative pharmaceuticals. He also highlights the unique roles that fungi play in our ecosystem, including their potential for sustainable technologies, and stresses the urgency of addressing fungal resistance before it's too late.
Climate change is enabling fungi to thrive at human body temperatures, raising concerns about the potential for future pandemics.
While fungi pose significant health risks, they also offer numerous benefits across industries, emphasizing the need for balanced research.
Deep dives
The Potential Threat of Fungal Pathogens
Fungi, often perceived as benign, could pose significant health risks if they adapt to higher temperatures due to climate change. Research indicates that as global warming progresses, certain fungi may develop the capability to thrive at human body temperatures, potentially leading to pandemic scenarios. Key examples include the cordyceps fungus, which has been fictionalized in media but mirrors real scientific concerns about fungi evolving new pathogenic capabilities. This adaptation raises alarms about the potential for a future fungal pandemic, highlighting the importance of preparing for such unexpected health threats.
Emerging Challenges with Candida auris
Candida auris, a fungus that emerged in the medical field only recently, has become a significant cause for concern due to its rapid spread across multiple continents. This drug-resistant yeast is particularly dangerous for immunocompromised individuals, demonstrating how fungi can adapt to human environments and weaknesses. Recent studies suggest that this global spread may be linked to environmental factors, particularly climate change, serving as an early warning of the evolving capabilities of previously non-threatening fungi. The rise of such pathogens underscores the urgent need for increased awareness and proactive measures in fungal disease research and treatment.
The Dual Nature of Fungi: Risks and Innovations
While there are considerable risks associated with pathogenic fungi, their potential benefits to society cannot be overlooked. Fungi are essential in various industries, from food production to medicine, and offer innovative solutions for sustainable materials, including biodegradable options for packaging and construction. Advancements in biotechnology could harness fungi for environmental applications, such as improved air conditioning systems using mushroom properties or even creating fungal-based filters for water purification. This dual nature prompts a reevaluation of how fungi can be both a threat and a resource, calling for balanced research and development in this remarkable kingdom of life.
Five years after COVID became a global pandemic, could another health crisis be on our horizon? According to scientists who study diseases, the possibility of a fungal pandemic—the subject of science fiction TV shows like “The Last of Us,” could be more of a reality, thanks to climate change and our warming planet. As fungi are adapting to warmer climates, they are becoming increasingly stronger and more resistant against the drugs we have to fight them.
Arturo Casadevall is one of the scientists who is warning against fungi's powerful potential. He's a professor of microbiology and immunology at the Johns Hopkins’ Bloomberg School of Public Health and the author of the new book, What If Fungi Win? He explains why fungi are becoming a growing public health threat, and what tools we have to protect ourselves from a future fungal outbreak.
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