LEVELS – A Whole New Level #282 - Longevity biomarkers for healthy aging and well-being | Dr. Matt Kaeberlein & Mike Haney
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Sep 25, 2025 Join Matt Kaeberlein, a molecular biologist and expert on aging, as he dives into fascinating longevity biomarkers and how they can influence healthy aging. He discusses the crucial differences between lifespan, health span, and ‘sick span.’ Kaeberlein emphasizes the importance of emotional health and community in longevity while critiquing the practicality of certain cellular tests. He also highlights lifestyle changes that can dramatically improve health span and shares insights on protein intake, exercise priorities, and the potential of the drug rapamycin.
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Lifespan Up, Healthspan Down
- Lifespan rose while healthspan declined because chronic disease years expanded across populations.
- Poor lifestyle and a healthcare system that waits until people are sick largely explain worsening population health.
Biological Age Tests Are Risk Estimates
- 'Biological age' tests measure correlates of risk, not a true single biological age.
- These clocks estimate current health status or mortality risk but do not measure a direct mechanistic age.
Build A Foundational Health Assessment
- Start with foundational tests: comprehensive blood work and DEXA body composition.
- Add functional exercise assessment and sleep and emotional-health screening to target the weakest pillar.