The Consistency Project Beat Anabolic Resistance: Train Hard, Eat 0.7 g/lb Protein, Win
Oct 15, 2025
Explore the concept of anabolic resistance and its effects on muscle mass as we age. Discover how obesity and insulin resistance can impair muscle protein synthesis. Learn the critical role of resistance training in promoting muscle growth. Find out why a protein intake of 0.7 g per pound is a practical target for most individuals. Dive into practical non-nutritional strategies to counteract muscle loss and gain reassurance that itās never too late to start weight training for strength. Get ready to challenge your fitness routine!
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What Anabolic Resistance Means
- Anabolic resistance means a blunted muscle protein synthesis (MPS) response which can lead to muscle loss if sustained.
- MPS is an acute response and doesn't alone determine long-term muscle mass balance.
Age Isn't The Main Driver
- Most studies do not find a direct effect of chronological age on anabolic resistance across feeding scenarios.
- Age often correlates with other drivers, so age per se may not be the primary cause.
Obesity And Sedentary Lifestyle Drive Resistance
- Obesity and sedentarism are the primary drivers behind anabolic resistance, not age alone.
- Insulin resistance in obesity reduces amino acid uptake into muscle, blunting MPS.