Could a single molecule be the difference between vibrant longevity and early decline?

Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal the real key to living longer, fighting disease, and maximizing your energy: NAD.

This master molecule fuels your mitochondria, DNA repair, and cellular resilience, but here’s the catch—it plummets as you age. That means more fatigue, brain fog, inflammation, and higher risks of disease. But what if you could stop the decline and even reverse it?

Dr. Salzman breaks down the game-changing science behind NAD, CD38, and cellular repair—and the fastest, most effective ways to optimize your levels for peak performance, health, and longevity.

Get ready to rethink everything you thought you knew about aging, pharmaceuticals vs. supplements, and the radical new approach to living better, longer.

What You’ll Learn:

• The #1 reason your NAD is disappearing—and how to fix it

• Why NAD is the missing link in energy, DNA repair, and disease prevention

• The hidden enzyme (CD38) that’s sabotaging your longevity

• How to supercharge mitochondria, optimize blood flow, and fight aging at the source

• Why the supplement industry has it wrong—and the best way to boost NAD naturally

• The shocking truth about the FDA, pharmaceuticals, and the future of anti-aging medicine

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Wonderfeel Instagram – https://www.instagram.com/getwonderfeel/

• Wonderfeel Supplement : https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast • 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

00:00 Trailer

01:07 Introduction and Episode Overview

02:29 Meet Dr. Andrew Salzman

02:36 From Physician to Researcher

03:39 Pharmaceuticals vs. Nutritionals

04:17 The Role of NAD in Longevity

06:32 Challenges in Longevity Research

12:58 Understanding NAD and PARP

14:34 NAD’s Impact on Health

23:19 Gut Health and Longevity

27:43 Innovations in NAD Supplementation

41:27 Customer Feedback and Product Effectiveness

42:41 Surprising Benefits of NAD for Sexual Health

44:47 NAD and Vascular Health

48:46 NAD’s Role in Aging and Longevity

54:03 NAD and Lifestyle Choices

01:03:02 NAD and Cognitive Function

01:06:18 NAD and Exercise

01:13:42 NAD and Sleep

01:21:54 Final Thoughts on NAD and Longevity

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97: A Very Lucky Lady