Short Wave The Future Of Immune Health Might Be Here
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Nov 12, 2025 
Join John Tsang, a Yale immunology professor and creator of the Immune Health Metric, alongside David Ewing Duncan, a journalist renowned for his self-experimentation in health science. They explore the revolutionary immune health assessment that could predict diseases before they manifest. David shares his personal experience with immune profiling, revealing how this metric indicated an immune age significantly younger than his actual age. Their discussion also highlights the Human Immunome Project and its potential to reshape our understanding of immune health.
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Decades Of Self-Experimentation
- David Ewing Duncan has collected ~70 terabytes of personal health data over 25 years of self-experimentation.
- He says most was useless, but John Tsang's immune metric produced the most meaningful insight he'd seen.
Immune System As Bodywide Sentinel
- The immune system patrols trillions of cells across organs and adapts future responses based on past exposures.
- John Tsang emphasizes immune memory drives how the body anticipates threats like flu or COVID.
Limits Of The CBC
- The standard CBC only counts blood cells and gives limited insight into where or what the problem is.
- John Tsang and David note CBCs are insufficient to link cell counts to overall immune health.