Precision Longevity Medicine with Dr. David Barzilai

Feb 5, 2025

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Can personalized medicine unlock the secrets to living longer and healthier lives? In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. David Barzilai, a renowned longevity physician and founder of Barzilai Longevity Consulting, to explore the science of extending healthspan through precision and innovation.

Dr. Barzilai shares his journey into biogerontology and longevity science, unpacking key concepts like the hallmarks of aging, the potential of lifestyle interventions, and the translation of findings from animal models to human health. He highlights how evidence-based lifestyle medicine—centered on nutrition, exercise, sleep, and stress management—can be tailored to individual needs using biomarker-driven strategies for maximum impact.

The conversation delves into some of the most promising longevity interventions, from gerotherapeutics to cutting-edge supplements. Dr. Barzilai emphasizes the power of personalized approaches in optimizing healthspan and lifespan, offering listeners practical, science-backed insights to take charge of their longevity journey.

Engaging and informative, this episode is essential listening for anyone curious about the future of longevity medicine and the innovations shaping how we age.

Guest-at-a-Glance
💡 Name: Dr. David Barzilai, MD, PhD

💡What he does: Founder and CEO

💡Company: Healthspan Coaching LLC

💡Noteworthy: Renowned longevity physician integrating science and personalized health strategies.

💡 Where to find them: LinkedIn, Twitter

Episode highlights:

Introduction: 00:00:00
Dr. Barzilai’s Journey into Science: 00:03:43
The Importance of Translating Science into Practice: 00:10:00
The Role of Social Media in Longevity Science: 00:16:37
Defining Biogerontology: 00:22:32
Understanding the Hallmarks of Aging: 00:24:27
The Role of Lifestyle Medicine in Preventing Premature Mortality: 00:36:13
Caloric Restriction and Its Effects on Lifespan: 00:37:33
Human Trials and the Challenges of Compliance: 00:41:13
The Potential of Rapamycin and mTOR Inhibitors: 00:42:05
The Importance of Lifestyle Medicine: 00:51:25
Precision Medicine: Tailoring Health Interventions: 01:02:56
GLP-1 and Alcohol Absorption: 01:12:30
Exercise and Mortality Reduction: 01:15:33
Biomarkers and Metabolic Health: 01:19:38
Longevity Drugs and Supplements: 01:25:43
Epigenetic Reprogramming and Aging: 01:45:06

For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast