Barbell Shrugged The Truth About GLP-1 Medications w/ Dr. Garrett Butler, Anders Varner, Doug Larson, and Travis Mash #798
May 14, 2025
Dr. Garrett Butler, a family physician in rural West Virginia, explores the fascinating world of GLP-1 medications. He discusses their origins linked to the Gila monster and transformative roles in diabetes management and weight loss. The conversation delves into how these medications impact insulin and gut motility while considering individual responses to treatment. Butler also highlights the importance of lifestyle changes alongside medication and addresses the risks associated with GLP-1, emphasizing the need for informed patient-provider conversations.
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GLP-1 Origin and Development
- GLP-1 molecules originated from studying Gila monster saliva and help regulate glucose and insulin in the body.
- Semaglutide, developed from this research, became the effective drug Ozempic for diabetes and weight loss.
How GLP-1 Controls Appetite
- GLP-1 slows gut motility making you feel full longer and increases insulin production.
- It also affects brain receptors that control satiety and reward pathways, impacting appetite and cravings.
Variable Patient Responses to GLP-1s
- GLP-1 medications show variable weight loss results; some patients lose significant weight, others do not.
- Benefits also include improved blood sugar, blood pressure, and cholesterol independent from weight loss.