Can you imagine unlocking the secret to longevity through a powerful compound discovered on a remote island? 

In this episode of the Biohacking Superhuman Podcast, we chat with Dr. Ross Pelton, a renowned scientist and author, about rapamycin, a compound with untold potential for revolutionizing health and extending life. Together, we trace rapamycin’s fascinating history from its origins on Easter Island to its current potential as an awe-inspiring life-extending compound, delving into its dual mechanisms - mTOR and autophagy - for a fresh outlook on cellular metabolism and the aging process.

The intricate balance between mTOR and autophagy plays a pivotal role in achieving healthy longevity - a balance that our ancestors maintained effortlessly due to their lifestyle but has been upset by our modern way of living. With Dr. Pelton, we'll explore how to restore this equilibrium through intermittent fasting, exercise, a healthy diet, and of course, rapamycin. We also discuss the importance of dosing, frequency of use, and the intriguing concept of "rectangularization of the aging curve." 

Ross Pelton is a pharmacist, nutritionist, author and a health educator who is widely recognized as the world’s leading authority on drug-induced nutrient depletions. He was named one of the top 50 most influential pharmacists in the United States by American Druggist magazine for his work in Natural Medicine.

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Website: https://www.naturalpharmacist.net/ 

Book: https://www.amazon.ca/Rapamycin-mTOR-Autophagy-Treating-Syndrome/dp/1607660156 

What we discuss:

(0:00:03) - About Rapamycin

(0:13:03) - Balancing mTOR and Autophagy Importance

(0:19:38) - Rapamycin, Fasting, and the Microbiome

(0:32:32) - Rapamycin Dosage and Monitoring

(0:40:46) - Benefits of Rapamycin for Aging

(0:47:43) - Dietary Factors in Protein and Rappamycin

(0:58:32) - Postbiotic Metabolites and Gut Health

(1:08:22) - Plant-Based Diet and Probiotics for Microbiome

(1:16:03) - Japanese Fermentation and Gut Microbiome

Key takeaways:

• Rapamycin has the potential to be life-saving due to its two powerful mechanisms: mTOR and autophagy. It was discovered on Easter Island in 1966 and approved for kidney transplant patients in 1996 by the FDA. It has potential as a revolutionary new type of chemotherapy and can be used to better understand cellular metabolism and the aging process. 

• When it comes to achieving healthy longevity, balance between mTOR and autophagy is essential. Our ancestral humans achieved this naturally due to their lifestyle of eating once a day, spending four hours digesting their food, and sometimes going two or three days without nutrient intake. But today, food is available all the time, leading to an over-activation of mTOR and a lack of autophagy. To restore the balance, intermittent fasting, rapamycin, exercise, and eating healthy are advocated. 

• When it comes to rapamycin, it's important to remember that it won't override bad habits and it's not a miracle quick fix. To gain the full benefits, a reasonable diet, exercise, and sleep regularly are necessary.