The science behind how sickness shapes your mood | Keely Muscatell
Dec 1, 2023
auto_awesome
Social neuroscientist Keely Muscatell discusses the interconnectedness of mood and the inflammatory system, explaining why sickness can lead to depression. She explores the impact of changes in the immune system on psychological well-being, social behavior, and the inflammatory response. Muscatell also discusses the influence of inflammation on social interactions, the role of stress, and how psychological stress can activate the immune system and affect mood.
Sickness can affect our mood and social behavior due to the interconnectedness of our immune system and inflammatory response.
Inflammation may have an evolutionary purpose to prompt us to conserve energy by resting and prioritizing interactions with close support figures or loved ones.
Deep dives
Physiological changes during sickness affect mood and social behavior
During sickness, the physiological changes in our body not only cause physical symptoms like fever and fatigue but also shape our mood and social behavior. Research in social psychonuroimmunology reveals that changes in the immune system can signal the brain to think, feel, and act differently. Inflammation, driven by pro-inflammatory cytokines, not only causes physical symptoms but also makes us feel down, depressed, and socially withdrawn. This indicates the powerful influence the immune system has on our mood and social interactions.
Evolutionary purpose of immune responses affecting mood and social behavior
The immune system's ability to manipulate the brain and cause feelings of sadness and social withdrawal may have an evolutionary purpose. Revving up the immune system requires a lot of energy, and it wants us to conserve calories by staying at home and resting when we're sick. Inflammation can make activities less enjoyable and interacting with others seem exhausting, thus reducing our likelihood of engaging in energy-consuming social interactions. In short-term situations, the immune-to-brain signaling is considered adaptive, guiding us to prioritize rest and recovery.
Selective social interactions influenced by inflammation
Inflammation doesn't always make us entirely socially withdrawn; it can make us more motivated to seek social interactions with those closest to us. Research indicates that while inflammation might dampen our interest in socializing with strangers, it can enhance the reward response in the brain when interacting with support figures or loved ones. This suggests that inflammation may make us more selective about the people we choose to socialize with, focusing on those who can provide comfort and care.
Your immune system is more socially aware than you think, says social neuroscientist and psychology professor Keely Muscatell. Investigating the interconnectedness of your mood and your inflammatory system, she offers an evolutionary reason as to why being sick may make you feel depressed — and vice versa.