John reacts to the 49ers dominant win over the Giants and shines a spotlight on the ONE question mark on the 49ers roster. He explains that Christian McCaffrey has completely changed the Niners, and breaks down why the Giants are in serious trouble.

He predicts the NFC will be a three horse race, assesses the impact of the season ending injury to Trevon Diggs, and thinks a certain head coach could be fired by Monday should his team lose this weekend.

Stuckey from the Action Network joins John to talk about some of the best bets of the weekend.

Follow John on Twitter, Instagram and YouTube for the latest. Check out Gametime - the fastest growing ticketing app in the US, and the official ticketing app of 3 & Out and GoLow - for tickets to all of your favorite NFL, NBA, NHL, NCAA teams. Concert and comedy show tickets, too. Go to Gametime now to create an account, download the app and use code JOHN for $20 off your first purchase. #Volume #Herd

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3 and Out - TNF Reaction, 49ers Stacked, Magnificent McCaffrey, Diggs Injury