The Joe Rogan Experience #2420 - Chris Masterjohn
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Nov 29, 2025 
Chris Masterjohn, PhD, a nutritional scientist and host of the Mastering Nutrition podcast, delves into fascinating topics around mitochondria and nutrition. He debunks the turkey-tryptophan myth and reveals how sleep acts as mitochondrial rest. Masterjohn discusses the broader benefits of creatine beyond muscle performance, including cognitive health, and highlights the importance of sunlight for producing glutathione. He also warns about megadosing nutrients and emphasizes a food-first approach to health, advocating for diversified exercise and testing for mitochondrial stress.
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Sleep As Mitochondrial Recharge
- Deep sleep gives mitochondria a rest so they can rebuild energy reserves and repair cellular machinery.
- Chris Masterjohn links sleep’s core purpose to mitochondrial recovery rather than just dreaming or melatonin effects.
Creatine Is A Systemic Energy Shuttle
- Creatine acts like an energy distribution grid, helping mitochondria supply ATP across tissues.
- Acute creatine improved cognitive performance and reduced tiredness during sleep deprivation in trials.
Use Morning Light Then Red/NIR Therapy
- Use red and near-infrared light to stimulate mitochondria and order mitochondrial water structure for better ATP production.
- Start with morning sunlight as a base and add red/near-infrared devices if needed.
