Sudden Infant Death Syndrome by R. Goldstein | OPENPediatrics

Oct 21, 2022

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October is Sudden Infant Death Syndrome awareness month. Dr. Richard Goldstein, director of Robert’s Program on Sudden Unexplained Death in Pediatrics, provides an overview of Sudden Infant Death Syndrome (SIDS), including historical perspectives, definitions, current understanding of potential etiologies, and emerging research. Additionally, Dr. Goldstein offers practical tips for speaking with caregivers about SIDS. After this podcast, listeners will be able to: -Discuss the historical background of Sudden Infant Death Syndrome (SIDS) -Describe key terminology regarding SIDS and Sudden Unexplained Death in Pediatrics -Identify some of the proposed mechanisms related to SIDS -Discuss practical advice for speaking with families and caregivers Publication date: October 21, 2022. Articles referenced: • Goldstein RD, Kinney HC, Guttmacher AE. Only Halfway There with Sudden Infant Death Syndrome. N Engl J Med. 2022;386(20):1873-1875. (0:44) • MacDorman MF, Rosenberg HM. Trends in infant mortality by cause of death and other characteristics, 1960-88. Vital Health Stat 20. 1993;(20):1-57. (2:40) • Mitchell EA, Thach BT, Thompson JMD, Williams S, for the New Zealand Cot Death Study. Changing Infants' Sleep Position Increases Risk of Sudden Infant Death Syndrome. Arch Pediatr Adolesc Med. 1999;153(11):1136–1141. (2:48) • Haynes RL, Frelinger AL 3rd, Giles EK, et al. High serum serotonin in sudden infant death syndrome. Proc Natl Acad Sci U S A. 2017;114(29):7695-7700. (17:20) • Kinney HC, Haynes RL, Armstrong DD, et. al. Abnormalities of the Hippocampus in Sudden and Unexpected Death in Early Life. In: Duncan JR, Byard RW, eds. SIDS Sudden Infant and Early Childhood Death: The Past, the Present and the Future. University of Adelaide Press; 2018. (19:09) • Koh HY, Haghighi A, Keywan C, et al. Genetic Determinants of Sudden Unexpected Death in Pediatrics. Genet Med. 2022;24(4):839-850. (22:50) • Miller MB, Huang AY, Kim J, et al. Somatic genomic changes in single Alzheimer's disease neurons. Nature. 2022;604(7907):714-722. (30:45) • Warland J, O'Leary J, McCutcheon H, Williamson V. Parenting paradox: parenting after infant loss. Midwifery. 2011;27(5):e163-e169. (36:10) • Kinney HC, Richerson GB, Dymecki SM, Darnall RA, Nattie EE. The brainstem and serotonin in the sudden infant death syndrome. Annu Rev Pathol. 2009;4:517-550. (42:01) Additional references: • Recent article in "Inside Precision Medicine" quoting Dr. Goldstein https://bit.ly/3TzhG4j • Back to Sleep campaign: https://safetosleep.nichd.nih.gov/activities/campaign • https://www.childrenshospital.org/programs/roberts-program/clinician-resources • https://undiagnosed.hms.harvard.edu/ • https://www.broadinstitute.org/ • https://medicine.uiowa.edu/humangenetics/clinical-genetics/health-care-providers • https://www.genomeweb.com/informatics/microsoft-seattle-childrens-seek-genetic-markers-sids-through-whole-genome-sequencing#.Y1GOi-zMJqs • https://med.nyu.edu/departments-institutes/pediatrics/divisions/clinical-genetics/pediatric-undiagnosed-diseases-program • https://www.australiangenomics.org.au/research/the-australian-undiagnosed-diseases-network/ • https://ojrd.biomedcentral.com/articles/10.1186/s13023-021-02089-5 Citation: Goldstein R, Daniel D, Wolbrink T. Sudden Infant Death Syndrome. 10/22. Online Podcast. OPENPediatrics. https://youtu.be/pu-gnSCHDhw. OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access and thus at no expense to the user.