Dr. Adeel Khan, leading expert in regenerative medicine, discusses advancements in tissue engineering, cell therapy, and gene therapy. He explores the link between dementia and type three diabetes, introduces clotho peptide for neuroprotection, and discusses the use of E. coli as a carrier for peptides. The future of regenerative medicine is highlighted, emphasizing responsible advancement and global leaders in the field.
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Quick takeaways
Regenerative medicine advancements include tissue engineering, cell therapy, and gene therapy.
Ethical considerations surrounding genetic engineering in regenerative medicine.
Collaboration, responsible research, and regulation are crucial for safe and effective advancements in regenerative medicine.
Deep dives
Advancements in Regenerative Medicine
In this podcast episode, the host discusses the advancements in regenerative medicine with Dr. Adil Khan, who is described as the Elon Musk of regenerative medicine. They explore topics such as tissue engineering, genetic editing, and the potential for extending human lifespan. Dr. Khan's work focuses on using genetic engineering techniques to manipulate stem cells and create induced pluripotent stem cells (IPSCs), which have similar properties to embryonic stem cells without the ethical concerns. The conversation also touches on the importance of accessibility and equity in providing these medical innovations to everyone, rather than widening the gap between the rich and poor.
Benefits and Applications of Genetic Engineering
One of the main focuses of the podcast episode is genetic engineering and its potential applications in regenerative medicine. They discuss the idea of editing embryos to select for certain traits, but also raise ethical concerns regarding inequality and the commodification of human traits. Dr. Khan explains how genetic engineering can be used to create specific gene therapies, like the bliss gene, which could enhance happiness and well-being. They also explore the use of gene therapy to treat rare diseases and the importance of ensuring safety and efficacy in these innovative treatments.
Challenges and Considerations in Regenerative Medicine
The podcast delves into the challenges and considerations in the field of regenerative medicine. They address concerns about the potential misuse or mishandling of these technologies, highlighting the importance of responsible research and ethical practices. The discussion touches on potential risks and the need for proper regulation and oversight to prevent harmful consequences. Additionally, they emphasize the need for collaboration and open dialogue in the scientific community to ensure safe and effective advancements in regenerative medicine that benefit society as a whole.
Potential to Extend Lifespan
The podcast explores the potential to extend lifespan by addressing the hallmarks of aging, such as telomere attrition and chronic inflammation. By turning off or slowing down these hallmarks, it is possible to delay the aging process and potentially extend lifespan. One example mentioned in the podcast is the use of gene therapy to increase the production of follistatin, a peptide that inhibits myostatin and can reverse aging. This therapy has shown promising results, with one hyper responder experiencing a reduction in intrinsic biological age by 63 years.
Muscle Mass and Immune System Health
The podcast highlights the importance of muscle mass in preventing immune dysfunction and aging-related conditions. It is suggested that having muscle mass helps maintain t-regulatory cells, which regulate the immune system and prevent immune dysfunction. By preserving these cells and preventing immune senescence, inflammation in the brain, and conditions like dementia can be reduced. The podcast also mentions the development of a peptide called Clotho, which protects against neurodegeneration and has been shown to increase IQ. The combination of gene therapy, muscle preservation, and targeted peptide therapies is seen as a potential way to delay the aging process and maintain overall health and vitality.
Dr. Adeel Khan discusses the latest advancements in regenerative medicine, including tissue engineering, cell therapy, and gene therapy. He explains how these technologies are being used to treat a wide range of conditions and improve overall health and longevity. Dr. Khan also addresses the ethical considerations surrounding these treatments and the potential impact they could have on society.
About Dr Khan
Dr. Adeel Khan is a leading expert in regenerative medicine and the founder of an emerging biotech company called Eterna Health , which is focused on developing innovative cell and gene therapies. He has a background in orthopaedic surgery and has been at the forefront of advancements in the field of regenerative medicine.
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