The Natural State with Dr. Anthony Gustin 056: Siim Land - Fasting and Muscle Mass, a Deep Dive into mTOR, and Reaching Autophagy With and Without Fasting
Mar 25, 2019
Siim Land, a biohacking educator and author of Metabolic Autophagy, dives deep into the science of fasting and autophagy. He simplifies complex topics like the triggers of autophagy, the role of mTOR, and how to balance fasting with muscle maintenance. Siim shares practical fasting strategies, discusses the effects of exercise and diet, and offers tips for optimizing muscle mass while fasting. His insights on carb refeeding and the importance of metabolic flexibility make this conversation a must-listen for anyone interested in enhancing their health through fasting.
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What Autophagy Really Is
- Autophagy is cellular self-eating that recycles damaged components like mitochondria and proteins.
- It activates under nutritional or energy stress and supports reduced inflammation and longevity.
mTOR, Nutrients, And Speed Of Autophagy
- Autophagy depends on depleted amino acids and glucose which suppress mTOR and allow autophagy to ramp.
- People already on low-carb diets will enter autophagy faster than those on standard Western diets.
Use Stressors To Boost Autophagy
- Add exercise, cold or heat exposure to increase AMPK and accelerate autophagy.
- Prefer fasted workouts to more rapidly activate autophagy-related genes.
