Ozempic, Weight Loss, and the Metabolic Truth No One Is Talking About | Ashley Koff

Weight loss has always been a loaded topic, but in the era of Ozempic, it has become even more polarized. For some, GLP-1 medications feel like a long-overdue breakthrough. For others, they trigger fear, shame, or moral judgment. And for many women, they come with unexpected side effects, confusing outcomes, and the unsettling realization that losing weight doesn’t always mean feeling better.

In this episode of The Dr. Brighten Show, Dr. Jolene Brighten sits down with registered dietitian and nutrition expert Ashley Koff for a nuanced, science-forward conversation about weight loss and Ozempic—one that goes far beyond the scale. Together, they explore why weight loss alone is a flawed goal, what GLP-1 medications actually reveal about human physiology, and why women are being disproportionately affected by oversimplified approaches to metabolic health.

If you’ve ever wondered why weight loss feels harder than it “should,” why Ozempic works for some people but not others, or why your labs can look normal while your body feels anything but—this episode offers clarity.

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