Menopause Publication, A Letter to the Editor, and DUTCH’s Response
May 21, 2024
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Mark Newman, MS discusses the comparison between FDA-approved estrogen patches and gels to compounded estrogen creams, confusion in nomenclature of estrogen dose and absorption, differences in response between patches, gels, and creams, advancements in hormone monitoring research, importance of clinical outcomes and scientific literature in hormone therapy.
Proper monitoring of Hormone Replacement Therapy (HRT) is crucial, emphasizing the importance of different monitoring methods like saliva testing versus urine testing.
Understanding the complexities of dosing and absorption in hormone therapy, focusing on variations between patches, gels, and creams for optimizing treatment outcomes.
Deep dives
Importance of Proper Hormone Replacement Therapy (HRT) Monitoring
Proper monitoring of Hormone Replacement Therapy (HRT) is crucial, as highlighted in the podcast episode. The conversation around HRT and monitoring methods, such as saliva testing versus urine testing, was a key focus. Different approaches by providers, like the usage of physiological dosing or traditional HRT dosing, led to varied outcomes and misconceptions. Clarifying these misconceptions through scientific literature and addressing monitoring methods are essential for effective HRT management.
Challenges with Dosing and Absorption in Hormone Therapy
The podcast delves into the complexities of dosing and absorption in hormone therapy, specifically focusing on patches, gels, and creams. Variations in dosing labeling between these methods can lead to misunderstandings. For instance, the discrepancy in absorbed amounts between patches and creams can impact the effectiveness of the therapy. Understanding the pharmacokinetics and absorption rates for different hormone delivery systems is vital for optimizing treatment outcomes.
Emphasis on Evidence-Based Practice and Clinical Experience
The importance of evidence-based practice and leveraging clinical experience in hormone therapy was a central point of discussion. Balancing clinical outcomes data with individual patient needs and monitoring methods was highlighted. The podcast emphasized the significance of aligning dosing with proven clinical outcomes for conditions like bone protection, cardiovascular health, and brain function. Utilizing the full body of literature and critically evaluating common misconceptions in hormone therapy practice are essential components of providing effective care.
Menopause Publication, A Letter to the Editor, and DUTCH’s Response
Listen in to this episode of the DUTCH Podcast as Mark Newman, MS, discusses Dr. Pam Smith’s Letter to the Editor in response to our Menopause publication, a peer-reviewed study on the comparison between FDA-approved estrogen patches and gels to compounded estrogen creams.
Mark and Jaclyn examine the somewhat confusing nomenclature between estrogen dose amount and absorption amount, the differences in response between patches, gels, and creams, and how salivary versus urinary testing can tell different stories in a patient. They also discuss how the research around hormone monitoring has advanced over the years and the importance of paying attention to clinical outcomes as well as the full body of scientific literature available.