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Aging is the process of degradation and atrophy that occurs in our bodies at various levels, from cellular to systemic. Longevity aims to slow down aging and extend both health span and lifespan. The focus is shifting from delaying aging to reversing it, through interventions such as epigenetic reprogramming. Epigenetic reprogramming involves rejuvenating cells by providing them with mRNA factors in lipid nanoparticles. This process reminds the cells how to read DNA in a more optimal way. While localized interventions are being developed, the ultimate goal is to create systemic approaches that can rejuvenate the entire body.
Longevity research has matured over the years, with significant progress made in understanding and developing interventions. The field has seen the emergence of aging institutes, non-profit organizations, and academia that focus on studying and addressing aging. In recent years, venture capital and larger funds have started investing in longevity companies to bring these technologies to market. The goal is to create next-generation products that go beyond traditional lifestyle interventions and provide targeted rejuvenation for specific organs or areas of the body. Companies are developing technologies like epigenetic reprogramming for dermatology applications, resulting in thicker, more youthful skin.
Epigenetic reprogramming involves using lipid nanoparticles to deliver mRNA factors into cells, rejuvenating them at the molecular level. Through synthetic biology, new lipids have been developed along with specific mRNA factors called TURNAs. These instructions act as food for the cells and guide them to read DNA in a more youthful and optimal way. While early interventions focus on specific cells or tissues, the long-term goal is to have systemic approaches that rejuvenate the entire body. Epigenetic reprogramming has shown promising results in preclinical studies, and companies like Turn Bio are exploring applications in dermatology and hair rejuvenation.
The path to longevity involves a gradual improvement in various aspects of health and performance. Rejuvenation at the cellular level can lead to benefits such as thicker skin, improved neuroplasticity, regrowth of cartilage, enhanced vision, and improved hearing. While the full extent of rejuvenation for the whole body is still being explored, the goal is to provide systemic interventions that address multiple age-related issues. Longevity's exponential growth and the fast-paced development of interventions create hope for a future where living to advanced ages with optimal health becomes a reality. The precise dosage, frequency, and timing of interventions will be refined as research advances.
Supporting longevity and biotech is critical, as we are at a stage where interventions for extending human lifespan are being developed. By supporting this field now, we can contribute to the success of these interventions and potentially extend human life by thousands of years.
There is a growing trend of longevity clinics that focus on optimizing health and maximizing the potential for longevity. These clinics offer personalized care, monitoring, and guidance to help individuals optimize their lifestyle, nutrition, and overall wellbeing.
The longevity industry faces several challenges, including the development of effective delivery methods for therapies, the need for better predictive models beyond animal testing, and the significance of regulation to fast-track life-saving technologies. Overcoming these obstacles will be crucial for advancing the field of longevity.
Longevity advancements have the potential to greatly impact healthcare and society. The cost of healthcare could be reduced, and the economic productivity of individuals could increase. By prolonging health and improving well-being, longevity can lead to a more productive, innovative, and fulfilled population.
In this video, we delve into the frontier of longevity and the pursuit of living forever. The discussion of longevity sparks different reactions among people, with some rejecting the idea outright, deeming it unnatural or immoral.
At Zuzalu, two distinct groups emerged—the Health and Wellness tribe, focused on healthy lifestyles, and the longevity tribe, resembling crypto enthusiasts, passionately researching the silver bullet for eternal life.
We explore the two conversations of slowing down aging and accelerating rejuvenation, with a particular focus on the latter. Interviews with Patrick Linden, author of "The Case Against Death," Sergio Ruiz, an epigenetic reprogramming expert, and Michael Greer, founder of the Humanity app, shed light on the socio-cultural reactions, DNA reprogramming, and AI-driven longevity scoring.
While the pursuit of longevity faces regulatory challenges, its potential to eliminate diseases and revolutionize healthcare holds transformative power. The quest for extended health spans offers tremendous benefits for humanity's future.
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------ TIMESTAMPS:
0:00 Intro 1:30 Wellness vs Longevity
7:00 PATRICK LINDEN 9:30 The Pursuit of Immortality 12:30 We Want Choice 16:30 How Long Would You Live? 23:20 Now is the Time 27:00 Health is Longevity 33:30 Increasing Healthspan 36:30 The Case Against Death 41:40 How to Not Die
46:00 SERGIO RUIZ 48:45 Healthspan and Lifespan 52:50 Longevity Research 57:45 Epigenetic Reprogramming 1:05:30 Feeling Young 1:09:30 Longevity Escape Velocity 1:14:30 Challenges and Obstacles 1:18:30 The Economic Case
1:28:00 MICHAEL GEER 1:31:50 A Billion Years of Health 1:38:45 Utilizing Technology 1:43:45 Using AI for Health 1:46:15 Good Metrics to Track 1:52:00 Defining Health 1:55:00 The Humanity App 2:01:30 More Users, More Wearables 2:08:45 Get Healthier
------ RESOURCES:
Patrick Linden https://twitter.com/DrPatrickLinden?s=20
Sergio Ruiz https://twitter.com/Sergio_A_Ruiz?s=20
Michael Geer https://twitter.com/Geeria?s=20
The Case Against Death https://mitpress.mit.edu/9780262543163/the-case-against-death/
VitaDAO https://www.vitadao.com/
Animal Free Precision Medicine https://www.afpm.bio/
Humanity App https://www.humanity.health/
------ Not financial or tax advice. See our investment disclosures here: https://www.bankless.com/disclosures
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