Count to 10 - Anaesthetic Primary Podcast EP40 – Pain Physiology | Anaesthetic Primary Topic | Neurophysiology & Pain | CT10
Aug 7, 2025
Dive into the intriguing world of pain physiology, where sensory pathways and the transition from acute to chronic pain are dissected. Explore the different types of pain, including visceral and somatic experiences, especially during labor. Discover how neuropathic pain differs and how pain perception can change as we age. With a focus on practical insights and exam strategies, this discussion simplifies complex concepts, making the challenging aspects of pain easier to navigate.
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Four-Step Pain Framework
- Pain processing breaks into four steps: transduction, transmission, perception and modulation.
- Framing pain this way simplifies understanding mechanisms and treatments.
Distinct Nociceptors And Fibre Types
- Nociceptors include A-mechano and C-polymodal types responding to thermal, mechanical or chemical stimuli.
- A-delta fibres cause fast, sharp pain while C fibres mediate slow, dull, poorly localized pain.
Dorsal Horn Laminae Matter
- C fibres mainly terminate in Rexed lamina II (substantia gelatinosa) while A-delta fibres terminate in lamina I and V.
- These dorsal horn terminations shape neurotransmitter release and subsequent spinal processing.